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GPx2 was identified as a target of the Wnt signaling pathway and plays an important role in normal physiological processes, embryonal development, and pathological processes such as cancer (Zhao et al

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This action subsequently influences the metabolic process that needs NAD+

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36 Further-more, in the Age-Related Eye Disease Study (AREDS) cohort, a multicenter clinical trial of over 4,000 elderly (5580 years of age) men and women randomized to receive either a placebo or a cocktail of 500 mg of vitamin C, 400 IU of vitamin E, and 15 mg of -carotene for an average of 6.3 years, former smokers had a higher risk of cataract surgery than nonsmokers, and current smokers had a higher risk of cortical cataract